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Exhibit 21

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SUBSIDIARIES OF OPKO HEALTH, INC.

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NAME

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JURISDICTION OF INCORPORATION

OPKO Instrumentation, LLC

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Delaware

OPKO Pharmaceuticals, LLC

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Delaware

OPKO Diagnostics, LLC

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Delaware

ModeX Therapeutics, Inc.

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Delaware

OPKO Chile, S.A.

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Chile

Arama Natural Products Distribuidora, Ltda

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Chile

Pharmacos Exakta S.A. de C.V.

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Mexico

FineTech Pharmaceutical Ltd

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Israel

OPKO Health Europe, S.L.

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Spain

OPKO Biologics, Ltd

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Israel

OPKO Ireland Global Holdings, Ltd

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Ireland

OPKO Ireland, Ltd

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Ireland

OPKO Canada Corp, ULC

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Canada

OPKO Renal, LLC

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Canada

Curna, Inc.

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Delaware

BioReference Health, LLC, a Delaware company

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New Jersey

EirGen Pharma Limited

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Ireland

Transition Therapeutics, Inc.

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Canada

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